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Term Information

Accession
GO:0048010
Name
vascular endothelial growth factor receptor signaling pathway
Ontology
biological_process
Synonyms
VEGF receptor signaling pathway, VEGF receptor signalling pathway, VEGFR signaling pathway
Alternate IDs
None
Definition
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Source: GOC:signaling, GOC:ceb
Comment
In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
History
See term history for GO:0048010 at QuickGO
Subset
None
Feedback
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Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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Parents of vascular endothelial growth factor receptor signaling pathway (GO:0048010)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
vascular endothelial growth factor receptor signaling pathway [is_a relation] is_a  transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)
Children of vascular endothelial growth factor receptor signaling pathway (GO:0048010)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
vascular endothelial growth factor receptor-3 signaling pathway (GO:0036325) [is_a relation] is_a  vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor receptor-2 signaling pathway (GO:0036324) [is_a relation] is_a  vascular endothelial growth factor receptor signaling pathway
negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948) [RO:0002212 relation] RO:0002212  vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor receptor-1 signaling pathway (GO:0036323) [is_a relation] is_a  vascular endothelial growth factor receptor signaling pathway
positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949) [RO:0002213 relation] RO:0002213  vascular endothelial growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment (GO:0060851) [is_a relation] is_a  vascular endothelial growth factor receptor signaling pathway
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway (GO:0038033) [is_a relation] is_a  vascular endothelial growth factor receptor signaling pathway
regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947) [RO:0002211 relation] RO:0002211  vascular endothelial growth factor receptor signaling pathway
None.