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Term Information

Accession
GO:0046776
Name
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I
Ontology
biological_process
Synonyms
inhibition of host MHC class I molecule presentation by virus, negative regulation by virus of MHC class I cell surface presentation, suppression by virus of MHC class I cell surface presentation in host, suppression by virus of host MHC class I cell surface presentation, suppression by virus of host tapasin activity
Alternate IDs
GO:0039591
Definition
Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I transmembrane protein complex. One mechanism of suppression is by direct inhibition of host tapasin, a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response. Source: GOC:bf, GOC:add, PMID:10859382
Comment
None
History
See term history for GO:0046776 at QuickGO
Subset
None
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Parents of suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I (GO:0046776)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I [is_a relation] is_a  suppression by virus of host antigen processing and presentation (GO:0039588)
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I [RO:0002212 relation] RO:0002212  antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)

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