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retroviral 3' processing activity
Term Information
Accession
GO:0044824
Name
retroviral 3' processing activity
Ontology
molecular_function
Synonyms
3' processing reaction, 3'-processing activity
Alternate IDs
None
Definition
The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls.
Source:Reactome:R-HSA-164522,
PMID:22580823
Comment
This reaction may serve to remove heterogeneous extra bases from the viral DNA end, and to stabilize the integrase-DNA complex. The chemistry of cleavage is a simple hydrolysis by single-step transesterification.
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