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Term Information

Accession
GO:0044683
Name
methylthiol:coenzyme M methyltransferase activity
Ontology
molecular_function
Synonyms
methylthiol:coenzyme M methyl transferase activity
Alternate IDs
None
Definition
Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM. Source: PMID:9371433, MetaCyc:RXN-8125
Comment
This reaction is achieved by the catalysis of two successive steps carried out by the same enzyme - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M. With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC:2.1.1.90, methanol-corrinoid protein Co-methyltransferase, and EC:2.1.1.246, methylated methanol-specific corrinoid protein:coenzyme M methyltransferase). The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation.
History
See term history for GO:0044683 at QuickGO
Subset
None
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Parents of methylthiol:coenzyme M methyltransferase activity (GO:0044683)
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methylthiol:coenzyme M methyltransferase activity [is_a relation] is_a  methyltransferase activity (GO:0008168)

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EC
2.1.1.251
MetaCyc
RXN-8125
RHEA
32667