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T/G mismatch-specific endonuclease activity
Term Information
Accession
GO:0043765
Name
T/G mismatch-specific endonuclease activity
Ontology
molecular_function
Synonyms
V.EcoKDcm, Vsr mismatch endonuclease, very short patch repair protein, DNA mismatch endonuclease
Alternate IDs
None
Definition
Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine.
Source:PMID:17651368
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