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Term Information

Accession
GO:0043336
Name
site-specific telomere resolvase activity
Ontology
molecular_function
Synonyms
ResT, TelN
Alternate IDs
None
Definition
Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases. Source: PMID:11804598, GOC:jl
Comment
Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres.
History
See term history for GO:0043336 at QuickGO
Subset
None
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Parents of site-specific telomere resolvase activity (GO:0043336)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
site-specific telomere resolvase activity [is_a relation] is_a  catalytic activity, acting on DNA (GO:0140097)
site-specific telomere resolvase activity [BFO:0000050 relation] BFO:0000050  telomere maintenance (GO:0000723)

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