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Term Information

Accession
GO:0039579
Name
suppression by virus of host ISG15-protein conjugation
Ontology
biological_process
Synonyms
suppression by virus of host ISG15 activity
Alternate IDs
None
Definition
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 conjugation to a susbtrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives. Source: PMID:18604270, PMID:11157743
Comment
None
History
See term history for GO:0039579 at QuickGO
Subset
None
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Parents of suppression by virus of host ISG15-protein conjugation (GO:0039579)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
suppression by virus of host ISG15-protein conjugation [is_a relation] is_a  suppression by virus of host innate immune response (GO:0039503)

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