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Term Information

Accession
GO:0039530
Name
MDA-5 signaling pathway
Ontology
biological_process
Synonyms
IFIH1 signaling pathway, MDA-5 signalling pathway, melanoma differentiation-associated gene 5 signaling pathway, MDA5 signaling pathway
Alternate IDs
None
Definition
The series of molecular signals initiated by the binding of dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines. Source: PMID:33087405, PMID:19620789, GOC:bf
Comment
None
History
See term history for GO:0039530 at QuickGO
Subset
None
Feedback
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Parents of MDA-5 signaling pathway (GO:0039530)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MDA-5 signaling pathway [is_a relation] is_a  cytosolic pattern recognition receptor signaling pathway (GO:0002753)
Children of MDA-5 signaling pathway (GO:0039530)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of MDA-5 signaling pathway (GO:0039533) [RO:0002211 relation] RO:0002211  MDA-5 signaling pathway
positive regulation of MDA-5 signaling pathway (GO:1900245) [RO:0002213 relation] RO:0002213  MDA-5 signaling pathway
negative regulation of MDA-5 signaling pathway (GO:0039534) [RO:0002212 relation] RO:0002212  MDA-5 signaling pathway
None.