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Term Information

Accession
GO:0038109
Name
Kit signaling pathway
Ontology
biological_process
Synonyms
Kit signalling pathway, SCF signaling pathway, stem cell factor receptor signaling pathway, stem cell factor signaling pathway
Alternate IDs
None
Definition
The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell. Source: GOC:signaling, GOC:nhn, PMID:16129412
Comment
None
History
See term history for GO:0038109 at QuickGO
Subset
None
Feedback
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Parents of Kit signaling pathway (GO:0038109)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
Kit signaling pathway [BFO:0000050 relation] BFO:0000050  cellular response to stem cell factor stimulus (GO:0036216)
Kit signaling pathway [is_a relation] is_a  transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)
Kit signaling pathway [is_a relation] is_a  cytokine-mediated signaling pathway (GO:0019221)
Children of Kit signaling pathway (GO:0038109)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of Kit signaling pathway (GO:1900235) [RO:0002212 relation] RO:0002212  Kit signaling pathway
positive regulation of Kit signaling pathway (GO:1900236) [RO:0002213 relation] RO:0002213  Kit signaling pathway
stem cell factor receptor activity (GO:0005020) [BFO:0000050 relation] BFO:0000050  Kit signaling pathway
regulation of Kit signaling pathway (GO:1900234) [RO:0002211 relation] RO:0002211  Kit signaling pathway
None.