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nodal receptor complex
Term Information
Accession
GO:0038104
Name
nodal receptor complex
Ontology
cellular_component
Synonyms
ActRIIB.ALK4.EGF-CFC complex
Alternate IDs
None
Definition
A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell.
Source:
GOC:signaling,
PMID:15062104,
GOC:bf,
PMID:11024047
Comment
Nodal signals through activin receptors but (unlike activin) also requires EGF-CFC coreceptors (such as Cripto or Cryptic in mammals) to signal. This term is intended for receptor/co-receptor components and not a nodal-receptor complex.
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