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large latent transforming growth factor-beta complex
Term Information
Accession
GO:0038045
Name
large latent transforming growth factor-beta complex
Ontology
cellular_component
Synonyms
LLC, large latent complex
Alternate IDs
None
Definition
A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors.
Source:PMID:8680476,
Reactome:R-HSA-177107,
PMID:9805445,
GOC:bf,
PMID:2350783
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