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TCR signalosome
Term Information
Accession
GO:0036398
Name
TCR signalosome
Ontology
cellular_component
Synonyms
LAT signalosome, linker for activation of T cells signalosome
Alternate IDs
None
Definition
A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology.
Source:
GOC:krc,
PMID:22426112,
PMID:17534068,
PMID:20107804
Link
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Link
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Link
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