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MKS complex

Term Information

Accession
GO:0036038
Name
MKS complex
Ontology
cellular_component
Synonyms
MKS module, B9 complex, tectonic complex, tectonic-like complex, TCTN-B9D complex
Alternate IDs
None
Definition
A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane. Source: GOC:sp, PMID:21422230, GOC:cilia, PMID:21725307, PMID:26595381, PMID:21565611, PMID:22179047, PMID:26982032, PMID:25869670
Comment
Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme.
History
See term history for GO:0036038 at QuickGO
Subset
None
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Parents of MKS complex (GO:0036038)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
MKS complex [is_a relation] is_a  protein-containing complex (GO:0032991)
MKS complex [BFO:0000050 relation] BFO:0000050  ciliary transition zone (GO:0035869)

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None.