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mediator complex binding

Term Information

Accession
GO:0036033
Name
mediator complex binding
Ontology
molecular_function
Synonyms
None
Alternate IDs
None
Definition
Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. Source: GOC:yaf, PMID:18391015
Comment
None
History
See term history for GO:0036033 at QuickGO
Subset
None
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Parents of mediator complex binding (GO:0036033)
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mediator complex binding [is_a relation] is_a  protein-containing complex binding (GO:0044877)

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