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Term Information

Accession
GO:0035583
Name
sequestering of TGFbeta in extracellular matrix
Ontology
biological_process
Synonyms
negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta, negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta, sequestering of TGFbeta LLC in extracellular matrix, sequestering of TGFbeta large latency complex in extracellular matrix
Alternate IDs
None
Definition
Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins. Source: GOC:signaling, GOC:BHF, GOC:bf, PMID:20855508, PMID:12482908
Comment
None
History
See term history for GO:0035583 at QuickGO
Subset
None
Feedback
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Parents of sequestering of TGFbeta in extracellular matrix (GO:0035583)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
sequestering of TGFbeta in extracellular matrix [is_a relation] is_a  sequestering of extracellular ligand from receptor (GO:0035581)
sequestering of TGFbeta in extracellular matrix [is_a relation] is_a  negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)
sequestering of TGFbeta in extracellular matrix [is_a relation] is_a  maintenance of protein location in extracellular region (GO:0071694)

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None.