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Term Information

Accession
GO:0035279
Name
miRNA-mediated gene silencing by mRNA destabilization
Ontology
biological_process
Synonyms
gene silencing by miRNA, mRNA cleavage, mRNA cleavage involved in gene silencing by miRNA, mRNA c...
Alternate IDs
None
Definition
An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism. Source: GOC:dph, PMID:15196554, GOC:mtg_lung, PMID:14744438, PMID:21118121, PMID:23209154
Comment
None
History
See term history for GO:0035279 at QuickGO
Subset
None
Link to all annotated objects annotated to miRNA-mediated gene silencing by mRNA destabilization.
Link to all direct and indirect annotations to miRNA-mediated gene silencing by mRNA destabilization.
Link to all direct and indirect annotations download (limited to first 10,000) for miRNA-mediated gene silencing by mRNA destabilization.
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Parents of miRNA-mediated gene silencing by mRNA destabilization (GO:0035279)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
miRNA-mediated gene silencing by mRNA destabilization [is_a relation] is_a  miRNA-mediated gene silencing (GO:0035195)
miRNA-mediated gene silencing by mRNA destabilization [is_a relation] is_a  mRNA destabilization (GO:0061157)
Children of miRNA-mediated gene silencing by mRNA destabilization (GO:0035279)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
endoribonuclease activity, cleaving miRNA-paired mRNA (GO:0090624) [BFO:0000050 relation] BFO:0000050  miRNA-mediated gene silencing by mRNA destabilization
None.