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Term Information

Accession
GO:0035102
Name
PRC1 complex
Ontology
cellular_component
Synonyms
Polycomb repressive complex 1
Alternate IDs
None
Definition
A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. Source: GOC:bf, PMID:10412979
Comment
In Drosophila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner.
History
See term history for GO:0035102 at QuickGO
Subset
None
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Parents of PRC1 complex (GO:0035102)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
PRC1 complex [is_a relation] is_a  nuclear ubiquitin ligase complex (GO:0000152)
PRC1 complex [is_a relation] is_a  PcG protein complex (GO:0031519)

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None.