Planteome: Term Details for "amyloid-beta formation" (GO:0034205)

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Term Information

Accession: GO:0034205
Name: amyloid-beta formation
Ontology: biological_process
Synonyms: beta-amyloid formation, beta-amyloid polypeptide formation from APP, beta-amyloid polypeptide formation from amyloid precursor protein
Alternate IDs: None
Definition: The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP). Source: GOC:mah
Comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because amyloid-beta can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the amyloid-beta polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form amyloid-beta. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000).
History: See term history for GO:0034205 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to amyloid-beta formation.; Link to all direct and indirect annotations to amyloid-beta formation.; Link to all direct and indirect annotations download (limited to first 10,000) for amyloid-beta formation.
Feedback: Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0043170 macromolecule metabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0044238 primary metabolic process
GO:0043603 amide metabolic process
GO:0019538 protein metabolic process
GO:0042982 amyloid precursor protein metabolic process
GO:0006518 peptide metabolic process
GO:0042987 amyloid precursor protein catabolic process
GO:0050435 amyloid-beta metabolic process
GO:0034205 amyloid-beta formation
GO:1902430 negative regulation of amyloid-beta formation
GO:1902004 positive regulation of amyloid-beta formation
GO:1902003 regulation of amyloid-beta formation

Parents of amyloid-beta formation (GO:0034205)

subject	relation	object
amyloid-beta formation	is_a	amyloid precursor protein catabolic process (GO:0042987)
amyloid-beta formation	is_a	amyloid-beta metabolic process (GO:0050435)

Children of amyloid-beta formation (GO:0034205)

subject	relation	object
negative regulation of amyloid-beta formation (GO:1902430)	RO:0002212	amyloid-beta formation
regulation of amyloid-beta formation (GO:1902003)	RO:0002211	amyloid-beta formation
positive regulation of amyloid-beta formation (GO:1902004)	RO:0002213	amyloid-beta formation

amyloid-beta formation

Term Information

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Parents of amyloid-beta formation (GO:0034205)

Children of amyloid-beta formation (GO:0034205)

None.