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Term Information

Accession
GO:0032640
Name
tumor necrosis factor production
Ontology
biological_process
Synonyms
TNF production, cachectin production, TNF-alpha production, Tnfa production, tumor necrosis factor-alpha production, TNF alpha biosynthesis, TNF biosynthesis, TNF biosynthetic process, TNF-alpha biosynthesis, TNF-alpha biosynthetic process, tumor necrosis factor anabolism, tumor necrosis factor biosynthesis, tumor necrosis factor biosynthetic process, tumor necrosis factor formation, tumor necrosis factor secretion, tumor necrosis factor synthesis
Alternate IDs
GO:0042533, GO:1990774
Definition
The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. Source: GOC:mah, PMID:10891884, PMID:15560120
Comment
Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). That this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
History
See term history for GO:0032640 at QuickGO
Subset
gocheck_do_not_annotate
Feedback
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Parents of tumor necrosis factor production (GO:0032640)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
tumor necrosis factor production [is_a relation] is_a  tumor necrosis factor superfamily cytokine production (GO:0071706)
Children of tumor necrosis factor production (GO:0032640)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of tumor necrosis factor production (GO:0032760) [RO:0002213 relation] RO:0002213  tumor necrosis factor production
regulation of tumor necrosis factor production (GO:0032680) [RO:0002211 relation] RO:0002211  tumor necrosis factor production
negative regulation of tumor necrosis factor production (GO:0032720) [RO:0002212 relation] RO:0002212  tumor necrosis factor production
None.