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Term Information

Accession
GO:0031594
Name
neuromuscular junction
Ontology
cellular_component
Synonyms
NMJ, motor endplate
Alternate IDs
None
Definition
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. Source: GOC:nln
Comment
In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.
History
See term history for GO:0031594 at QuickGO
Subset
None
Feedback
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Parents of neuromuscular junction (GO:0031594)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
neuromuscular junction [is_a relation] is_a  synapse (GO:0045202)
Children of neuromuscular junction (GO:0031594)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
neuromuscular junction of somatic muscle (GO:0098527) [is_a relation] is_a  neuromuscular junction
excitatory neuromuscular junction (GO:0098520) [is_a relation] is_a  neuromuscular junction
postsynapse of neuromuscular junction (GO:0098975) [BFO:0000050 relation] BFO:0000050  neuromuscular junction
neuromuscular junction of myotube (GO:0098523) [is_a relation] is_a  neuromuscular junction
inhibitory neuromuscular junction (GO:0098521) [is_a relation] is_a  neuromuscular junction
NIF_Subcellular
sao1124888485
Wikipedia
Neuromuscular_junction