Planteome: Term Details for "death-inducing signaling complex" (GO:0031264)

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Term Information

Accession: GO:0031264
Name: death-inducing signaling complex
Ontology: cellular_component
Synonyms: DISC, DISC protein complex, death receptor-induced signaling complex, death receptor-induced signalling complex, death-inducing signalling complex
Alternate IDs: None
Definition: A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. Source: PMID:12628743, PMID:8521815, GOC:mtg_apoptosis, PMID:12655293
Comment: Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10.
History: See term history for GO:0031264 at QuickGO
Subset: goslim_pir
Related: Link to all annotated objects annotated to death-inducing signaling complex.; Link to all direct and indirect annotations to death-inducing signaling complex.; Link to all direct and indirect annotations download (limited to first 10,000) for death-inducing signaling complex.
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GO:0005575 cellular_component
GO:0110165 cellular anatomical entity
GO:0071944 cell periphery
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0098796 membrane protein complex
GO:0005886 plasma membrane
GO:0098797 plasma membrane protein complex
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0031266 TRAIL death-inducing signaling complex

Parents of death-inducing signaling complex (GO:0031264)

subject	relation	object
death-inducing signaling complex	is_a	plasma membrane protein complex (GO:0098797)

Children of death-inducing signaling complex (GO:0031264)

subject	relation	object
CD95 death-inducing signaling complex (GO:0031265)	is_a	death-inducing signaling complex
TRAIL death-inducing signaling complex (GO:0031266)	is_a	death-inducing signaling complex

Wikipedia: Death-inducing_signaling_complex