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Term Information

Accession
GO:0019907
Name
cyclin-dependent protein kinase activating kinase holoenzyme complex
Ontology
cellular_component
Synonyms
CAK complex, CDK-activating kinase complex
Alternate IDs
None
Definition
A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. Source: PMID:8752210, GOC:bhm
Comment
None
History
See term history for GO:0019907 at QuickGO
Subset
None
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Parents of cyclin-dependent protein kinase activating kinase holoenzyme complex (GO:0019907)
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cyclin-dependent protein kinase activating kinase holoenzyme complex [is_a relation] is_a  nuclear cyclin-dependent protein kinase holoenzyme complex (GO:0019908)
cyclin-dependent protein kinase activating kinase holoenzyme complex [is_a relation] is_a  enzyme activator complex (GO:0150005)
cyclin-dependent protein kinase activating kinase holoenzyme complex [is_a relation] is_a  carboxy-terminal domain protein kinase complex (GO:0032806)

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None.