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Term Information

Accession
GO:0019172
Name
glyoxalase III activity
Ontology
molecular_function
Synonyms
(R)-lactate hydro-lyase, D-lactate dehydratase, glutathione-independent glyoxalase activity
Alternate IDs
None
Definition
Catalysis of the reaction: methylglyoxal + H2O = D-lactate. Source: PMID:7848303, GOC:mcc, PMID:21696459, RHEA:27754
Comment
Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC:4.4.1.5 (lactoylglutathione lyase) and EC:3.1.2.6 (hydroxyacylglutathione hydrolase).
History
See term history for GO:0019172 at QuickGO
Subset
None
Feedback
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Parents of glyoxalase III activity (GO:0019172)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
glyoxalase III activity [is_a relation] is_a  hydro-lyase activity (GO:0016836)
glyoxalase III activity [BFO:0000050 relation] BFO:0000050  methylglyoxal catabolic process to lactate (GO:0061727)
glyoxalase III activity [BFO:0000050 relation] BFO:0000050  lactate biosynthetic process (GO:0019249)

This term has no children.

EC
4.2.1.130
MetaCyc
GLYOXIII-RXN
RHEA
27754