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phospholipid scramblase activity

Term Information

Accession
GO:0017128
Name
phospholipid scramblase activity
Ontology
molecular_function
Synonyms
None
Alternate IDs
None
Definition
Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. Source: PMID:20302864, PMID:20043909, GOC:cjm
Comment
Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases).
History
See term history for GO:0017128 at QuickGO
Subset
None
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Parents of phospholipid scramblase activity (GO:0017128)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
phospholipid scramblase activity [is_a relation] is_a  intramembrane lipid transporter activity (GO:0140303)
phospholipid scramblase activity [BFO:0000050 relation] BFO:0000050  plasma membrane phospholipid scrambling (GO:0017121)
phospholipid scramblase activity [is_a relation] is_a  phospholipid transporter activity (GO:0005548)
Children of phospholipid scramblase activity (GO:0017128)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of phospholipid scramblase activity (GO:1900163) [RO:0002213 relation] RO:0002213  phospholipid scramblase activity
regulation of phospholipid scramblase activity (GO:1900161) [RO:0002211 relation] RO:0002211  phospholipid scramblase activity
negative regulation of phospholipid scramblase activity (GO:1900162) [RO:0002212 relation] RO:0002212  phospholipid scramblase activity
phosphatidylserine exposure on apoptotic cell surface (GO:0070782) [BFO:0000051 relation] BFO:0000051  phospholipid scramblase activity
None.