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prefoldin complex
Term Information
Accession
GO:0016272
Name
prefoldin complex
Ontology
cellular_component
Synonyms
GIM complex
Alternate IDs
None
Definition
A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
Source:PMID:9630229,
GOC:jl,
PMID:17384227,
PMID:24068951
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