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Term Information

Accession
GO:0016218
Name
polyketide synthase activity
Ontology
molecular_function
Synonyms
PKS activity
Alternate IDs
None
Definition
Catalysis of a multistep reaction that produce polyketides through decarboxylative condensation of carboxylic acids. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization. Source: PMID:10631508
Comment
None
History
See term history for GO:0016218 at QuickGO
Subset
None
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Parents of polyketide synthase activity (GO:0016218)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
polyketide synthase activity [BFO:0000050 relation] BFO:0000050  polyketide biosynthetic process (GO:0030639)
polyketide synthase activity [is_a relation] is_a  catalytic activity (GO:0003824)

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None.