You are using the Cyverse mirror of the Planteome Ontology Browser. The main site is currently down for maintenance.

Term Information

Accession
GO:0007249
Name
I-kappaB kinase/NF-kappaB signaling
Ontology
biological_process
Synonyms
I-kappaB kinase/NF-kappaB signal transduction, canonical NF-kappaB signaling cascade, I-kappaB kinase/NF-kappaB cascade, activation of the inhibitor of kappa kinase, p50-dependent NF-kappaB signaling, NF-kappaB cascade
Alternate IDs
None
Definition
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: PMID:12773372, GOC:jl, GOC:bf, Reactome:R-HSA-209560
Comment
None
History
See term history for GO:0007249 at QuickGO
Subset
None
Feedback
Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of I-kappaB kinase/NF-kappaB signaling (GO:0007249)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
I-kappaB kinase/NF-kappaB signaling [BFO:0000051 relation] BFO:0000051  positive regulation of NF-kappaB transcription factor activity (GO:0051092)
I-kappaB kinase/NF-kappaB signaling [is_a relation] is_a  intracellular signal transduction (GO:0035556)
Children of I-kappaB kinase/NF-kappaB signaling (GO:0007249)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) [RO:0002213 relation] RO:0002213  I-kappaB kinase/NF-kappaB signaling
I-kappaB phosphorylation (GO:0007252) [BFO:0000050 relation] BFO:0000050  I-kappaB kinase/NF-kappaB signaling
epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade (GO:0038168) [BFO:0000051 relation] BFO:0000051  I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124) [RO:0002212 relation] RO:0002212  I-kappaB kinase/NF-kappaB signaling
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) [RO:0002211 relation] RO:0002211  I-kappaB kinase/NF-kappaB signaling
None.