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Term Information

Accession
GO:0006309
Name
apoptotic DNA fragmentation
Ontology
biological_process
Synonyms
DNA catabolic process during apoptosis, DNA catabolism during apoptosis, DNA fragmentation involved in apoptotic nuclear change, endonucleolytic DNA catabolic process involved in apoptosis, DNA fragmentation, chromatinolysis
Alternate IDs
GO:0008178
Definition
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. Source: GOC:dph, GOC:tb, PMID:15723341, PMID:23379520, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976
Comment
DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
History
See term history for GO:0006309 at QuickGO
Subset
None
Feedback
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Parents of apoptotic DNA fragmentation (GO:0006309)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
apoptotic DNA fragmentation [is_a relation] is_a  DNA catabolic process (GO:0006308)
apoptotic DNA fragmentation [BFO:0000050 relation] BFO:0000050  apoptotic nuclear changes (GO:0030262)
Children of apoptotic DNA fragmentation (GO:0006309)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of apoptotic DNA fragmentation (GO:1902510) [RO:0002211 relation] RO:0002211  apoptotic DNA fragmentation
negative regulation of apoptotic DNA fragmentation (GO:1902511) [RO:0002212 relation] RO:0002212  apoptotic DNA fragmentation
positive regulation of apoptotic DNA fragmentation (GO:1902512) [RO:0002213 relation] RO:0002213  apoptotic DNA fragmentation
None.