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anaphase-promoting complex
Term Information
Accession
GO:0005680
Name
anaphase-promoting complex
Ontology
cellular_component
Synonyms
anaphase promoting complex, cyclosome, APC
Alternate IDs
None
Definition
A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
Source:
GOC:jh,
GOC:vw,
PMID:10465783,
PMID:10611969
Comment
Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein.
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