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scavenger receptor activity

Term Information

Accession
GO:0005044
Name
scavenger receptor activity
Ontology
molecular_function
Synonyms
macrophage receptor activity
Alternate IDs
None
Definition
Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). Source: PMID:12379907, PMID:12621157, GOC:bf, PMID:20981357, PMID:11790542
Comment
Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0038187' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children.
History
See term history for GO:0005044 at QuickGO
Subset
goslim_chembl
Feedback
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Parents of scavenger receptor activity (GO:0005044)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
scavenger receptor activity [is_a relation] is_a  cargo receptor activity (GO:0038024)

This term has no children.

None.