Planteome: Term Details for "ubiquitin activating enzyme activity" (GO:0004839)

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Term Information

Accession: GO:0004839
Name: ubiquitin activating enzyme activity
Ontology: molecular_function
Synonyms: E1 ubiquitin-activating enzyme
Alternate IDs: None
Definition: Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. Source: GOC:BioGRID, Wikipedia:Ubiquitin-activating_enzyme
Comment: The ubiquitin activating enzyme catalyzes a ligation reaction.
History: See term history for GO:0004839 at QuickGO
Subset: None
Related: Link to all annotated objects annotated to ubiquitin activating enzyme activity.; Link to all direct and indirect annotations to ubiquitin activating enzyme activity.; Link to all direct and indirect annotations download (limited to first 10,000) for ubiquitin activating enzyme activity.
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BFO:0000001 entity
BFO:0000003 occurrent
BFO:0000015 process
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0043170 macromolecule metabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0044238 primary metabolic process
GO:0043412 macromolecule modification
GO:0003674 molecular_function
GO:0019538 protein metabolic process
GO:0003824 catalytic activity
GO:0036211 protein modification process
GO:0016874 ligase activity
GO:0070647 protein modification by small protein conjugation or removal
GO:0140657 ATP-dependent activity
GO:0140096 catalytic activity, acting on a protein
GO:0016877 ligase activity, forming carbon-sulfur bonds
GO:0032446 protein modification by small protein conjugation
GO:0016567 protein ubiquitination
GO:0008641 ubiquitin-like modifier activating enzyme activity
GO:0004839 ubiquitin activating enzyme activity

Parents of ubiquitin activating enzyme activity (GO:0004839)

subject	relation	object
ubiquitin activating enzyme activity	is_a	ubiquitin-like modifier activating enzyme activity (GO:0008641)
ubiquitin activating enzyme activity	BFO:0000050	protein ubiquitination (GO:0016567)

This term has no children.

EC: 6.2.1.45
Reactome: R-HSA-8865098; R-HSA-8852132; R-HSA-8852134; R-HSA-8852133; R-HSA-8865090; R-HSA-8865050