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CAAX-protein geranylgeranyltransferase activity

Term Information

Accession
GO:0004662
Name
CAAX-protein geranylgeranyltransferase activity
Ontology
molecular_function
Synonyms
GGTase-I activity, GGTaseI activity, geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity, geranylgeranyltransferase type I activity, protein geranylgeranyltransferase type I, type I protein geranyl-geranyltransferase activity
Alternate IDs
None
Definition
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. Source: EC:2.5.1.59, PMID:8621375
Comment
None
History
See term history for GO:0004662 at QuickGO
Subset
None
Feedback
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Parents of CAAX-protein geranylgeranyltransferase activity (GO:0004662)
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CAAX-protein geranylgeranyltransferase activity [is_a relation] is_a  protein geranylgeranyltransferase activity (GO:0004661)

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