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Term Information

Accession
GO:0004386
Name
helicase activity
Ontology
molecular_function
Synonyms
ATP-dependent helicase activity
Alternate IDs
GO:0008026
Definition
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. Source: GOC:jl
Comment
Note that most helicases catalyze processive duplex unwinding.
History
See term history for GO:0004386 at QuickGO
Subset
goslim_chembl
goslim_yeast
goslim_candida
goslim_pir
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Parents of helicase activity (GO:0004386)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
helicase activity [is_a relation] is_a  catalytic activity, acting on a nucleic acid (GO:0140640)
helicase activity [is_a relation] is_a  ATP-dependent activity (GO:0140657)
Children of helicase activity (GO:0004386)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of helicase activity (GO:0051095) [RO:0002211 relation] RO:0002211  helicase activity
negative regulation of helicase activity (GO:0051097) [RO:0002212 relation] RO:0002212  helicase activity
DNA/RNA helicase activity (GO:0033677) [is_a relation] is_a  helicase activity
RNA helicase activity (GO:0003724) [is_a relation] is_a  helicase activity
DNA helicase activity (GO:0003678) [is_a relation] is_a  helicase activity
positive regulation of helicase activity (GO:0051096) [RO:0002213 relation] RO:0002213  helicase activity