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Term Information

Accession
GO:0004222
Name
metalloendopeptidase activity
Ontology
molecular_function
Synonyms
metalloendoprotease activity, metalloendoproteinase activity
Alternate IDs
None
Definition
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. Source: https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, GOC:mah
Comment
None
History
See term history for GO:0004222 at QuickGO
Subset
None
Feedback
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Parents of metalloendopeptidase activity (GO:0004222)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
metalloendopeptidase activity [is_a relation] is_a  endopeptidase activity (GO:0004175)
metalloendopeptidase activity [is_a relation] is_a  metallopeptidase activity (GO:0008237)
Children of metalloendopeptidase activity (GO:0004222)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
regulation of metalloendopeptidase activity (GO:1904683) [RO:0002211 relation] RO:0002211  metalloendopeptidase activity
positive regulation of metalloendopeptidase activity (GO:1904685) [RO:0002213 relation] RO:0002213  metalloendopeptidase activity
metalloendopeptidase activity involved in amyloid precursor protein catabolic process (GO:1902945) [is_a relation] is_a  metalloendopeptidase activity
negative regulation of metalloendopeptidase activity (GO:1904684) [RO:0002212 relation] RO:0002212  metalloendopeptidase activity