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Term Information

Accession
GO:0003852
Name
2-isopropylmalate synthase activity
Ontology
molecular_function
Synonyms
3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity, ...
Alternate IDs
None
Definition
Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+. Source: RHEA:21524
Comment
Note that this function was formerly EC:4.1.3.12.
History
See term history for GO:0003852 at QuickGO
Subset
None
Link to all annotated objects annotated to 2-isopropylmalate synthase activity.
Link to all direct and indirect annotations to 2-isopropylmalate synthase activity.
Link to all direct and indirect annotations download (limited to first 10,000) for 2-isopropylmalate synthase activity.
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Parents of 2-isopropylmalate synthase activity (GO:0003852)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
2-isopropylmalate synthase activity [is_a relation] is_a  acyltransferase activity, acyl groups converted into alkyl on transfer (GO:0046912)

This term has no children.

EC
2.3.3.13
KEGG_REACTION
R01213
MetaCyc
2-ISOPROPYLMALATESYN-RXN
RHEA
21524