You are using the Cyverse mirror of the Planteome Ontology Browser. The main site is currently down for maintenance.

Term Information

Accession
GO:0003700
Name
DNA-binding transcription factor activity
Ontology
molecular_function
Synonyms
DNA binding transcription factor activity, gene-specific transcription factor activity, sequence-specific DNA binding transcription factor activity, bacterial-type DNA binding transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity, bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding, bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding, metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding, transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding, transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding, transcription factor activity, metal ion regulated sequence-specific DNA binding, nucleic acid binding transcription factor activity, transcription factor activity
Alternate IDs
GO:0001071, GO:0001204, GO:0001199, GO:0001131, GO:0000130, GO:0001151, GO:0001130
Definition
A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. Source: GOC:txnOH-2018
Comment
Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.
History
See term history for GO:0003700 at QuickGO
Subset
goslim_metagenomics
goslim_chembl
goslim_drosophila
goslim_plant
goslim_mouse
goslim_agr
goslim_candida
goslim_yeast
Feedback
Contact the Planteome feedback if you find mistakes or have concerns about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.

Filter results

Loading...
pending...
Parents of DNA-binding transcription factor activity (GO:0003700)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
DNA-binding transcription factor activity [is_a relation] is_a  transcription regulator activity (GO:0140110)
DNA-binding transcription factor activity [BFO:0000050 relation] BFO:0000050  regulation of DNA-templated transcription (GO:0006355)
DNA-binding transcription factor activity [BFO:0000051 relation] BFO:0000051  transcription cis-regulatory region binding (GO:0000976)
Children of DNA-binding transcription factor activity (GO:0003700)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981) [is_a relation] is_a  DNA-binding transcription factor activity
ligand-activated transcription factor activity (GO:0098531) [is_a relation] is_a  DNA-binding transcription factor activity
negative regulation of DNA-binding transcription factor activity (GO:0043433) [RO:0002212 relation] RO:0002212  DNA-binding transcription factor activity
DNA-binding transcription repressor activity (GO:0001217) [is_a relation] is_a  DNA-binding transcription factor activity
regulation of DNA-binding transcription factor activity (GO:0051090) [RO:0002211 relation] RO:0002211  DNA-binding transcription factor activity
DNA-binding transcription activator activity (GO:0001216) [is_a relation] is_a  DNA-binding transcription factor activity
positive regulation of DNA-binding transcription factor activity (GO:0051091) [RO:0002213 relation] RO:0002213  DNA-binding transcription factor activity
sigma factor activity (GO:0016987) [is_a relation] is_a  DNA-binding transcription factor activity
None.