You are using the Cyverse mirror of the Planteome Ontology Browser. The main site is currently down for maintenance.
marginal zone B cell differentiation
Term Information
Accession
GO:0002315
Name
marginal zone B cell differentiation
Ontology
biological_process
Synonyms
marginal zone B lymphocyte differentiation, marginal zone B-cell differentiation, marginal zone B-lymphocyte differentiation, marginal zone B cell development
Alternate IDs
None
Definition
The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
Source:ISBN:0781735149,
GOC:jal
Comment
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Link
to all annotated objects annotated to marginal zone B cell differentiation.
Link
to all direct and indirect annotations
to marginal zone B cell differentiation.
Link
to all direct and indirect annotations download (limited to first 10,000)
for marginal zone B cell differentiation.
Feedback
Contact the
Planteome feedback
if you find mistakes or have concerns
about the data you find here.
Comments, changes to terms, or requests for new ontology terms can be made at GO issue tracker on GitHub.