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Term Information

Accession
GO:0002314
Name
germinal center B cell differentiation
Ontology
biological_process
Synonyms
germinal center B lymphocyte differentiation, germinal center B-cell differentiation, germinal center B-lymphocyte differentiation, germinal center B cell development
Alternate IDs
None
Definition
The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA). Source: ISBN:0781735149, GOC:jal
Comment
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
History
See term history for GO:0002314 at QuickGO
Subset
None
Feedback
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Parents of germinal center B cell differentiation (GO:0002314)
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germinal center B cell differentiation [is_a relation] is_a  mature B cell differentiation involved in immune response (GO:0002313)

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