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release of cytochrome c from mitochondria

Term Information

Accession
GO:0001836
Name
release of cytochrome c from mitochondria
Ontology
biological_process
Synonyms
None
Alternate IDs
None
Definition
The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. Source: PMID:9560217, GOC:add, GOC:mah, PMID:12925707, GOC:mtg_apoptosis, ISBN:0721639976
Comment
The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011.
History
See term history for GO:0001836 at QuickGO
Subset
None
Feedback
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Parents of release of cytochrome c from mitochondria (GO:0001836)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
release of cytochrome c from mitochondria [BFO:0000050 relation] BFO:0000050  apoptotic signaling pathway (GO:0097190)
release of cytochrome c from mitochondria [is_a relation] is_a  apoptotic mitochondrial changes (GO:0008637)
Children of release of cytochrome c from mitochondria (GO:0001836)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of release of cytochrome c from mitochondria (GO:0090200) [RO:0002213 relation] RO:0002213  release of cytochrome c from mitochondria
regulation of release of cytochrome c from mitochondria (GO:0090199) [RO:0002211 relation] RO:0002211  release of cytochrome c from mitochondria
negative regulation of release of cytochrome c from mitochondria (GO:0090201) [RO:0002212 relation] RO:0002212  release of cytochrome c from mitochondria
None.