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pyrimidine dimer DNA N-glycosylase activity
Term Information
Accession
GO:0000704
Name
pyrimidine dimer DNA N-glycosylase activity
Ontology
molecular_function
Synonyms
None
Alternate IDs
None
Definition
Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
Source:PMID:9224623,
GOC:elh
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